The Iron Dome rocket defense system, reportedly to be deployed near Gaza in May, would deprive Hamas of its main leverage against Israel – the threat of rocket salvos.
Egypt's underground anti-tunnel barrier of steel beams, now under construction, could eventually cut Hamas' supply of cash and weapons.
The looming double squeeze is poised to limit Hamas' options and change the rules of engagement on Gaza's volatile, blockaded borders.
However, the Islamic militants remain firmly entrenched in the territory they seized from their Western-backed Fatah rivals in 2007.
Hamas has already struck back against the steel wall by trying to rally public opinion against Egypt and experts warn Hamas could attempt to renew suicide attacks in Israel if rockets are intercepted.
Hamas "can adjust to any new circumstances," said Ahmed Yousef, a political adviser to Hamas Prime Minister Ismail Haniyeh, without giving specifics. He said more pressure on the movement would only make it more popular.
Following IDF's cast lead operation in Gaza a year ago to stop the daily barrages, rocket and mortar fire ebbed but did not stop. Meanwhile, basic goods, cash and weapons kept coming in through tunnels from Egypt, in addition to limited humanitarian supplies Israel lets through one of its crossings into Gaza.
Israel's Iron Dome and Egypt's steel wall could change the equation, analysts said.
This "weakens the position of Hamas in the strip and confronts them with a challenge, on ... the Egyptian and the Israeli front," said Ephraim Halevy, former chief of the Mossad. "They will now have to devise a strategy to face up to these new developments."
Israel announced Wednesday that it successfully tested the Iron Dome system, which intercepts short-range missiles of the type fired from Gaza and Lebanon.
Developed at a cost of more than $200 million, it shoots down incoming rockets within seconds of their launch, the Defense Ministry said. The system is so sophisticated that it can almost instantly predict where a rocket will land, changing its calculations to account for wind, sun and other conditions in fractions of a second.
Security officials acknowledged the system is expensive and will probably not be able to stop every rocket. Nonetheless, they said it is an important development in protecting Israelis and will strike an important psychological blow to Hamas.
The first battery is to be deployed in May to shield the town of Sderot near Gaza, the most frequent target of rocket attacks in recent years.
Uzi Rubin, a former top Defense Ministry official who was in charge of the long range anti-missile Arrow project, said changes will be profound. "Until now, we were totally exposed to anyone in Gaza who had a rocket to shoot at Israel," he said. "The ability (of Hamas) to cause losses and casualties in Israel will be greatly diminished."
Abu Obeida, spokesman for Hamas' military wing Izzedine al Qassam declined comment on Iron Dome.
A Hamas security officer in Gaza City, who is not linked to the military wing, shrugged off Israel's shield, saying it would be very expensive to shoot down every rocket. He refused to be quoted by name, in keeping with Hamas practice.
Ted Postol, an expert on missile defense at the Massachusetts Institute of Technology, said he was not familiar with all the details of Iron Dome, but believed it could help protect small communities from direct hits.
However, he said it was not clear if the system could stop a massive rocket barrage, and the high cost could also be a problem.
A homemade projectile costs less than $200, he said, while intercepting one would cost around $100,000. However, experts say the cost will drop once the system is in mass production.
Rubin, the former Defense Ministry official, said the shield is worthwhile anyway, citing the high human and economic cost to communities that live under rocket threat.
For now, cross-border friction typical of the recent years still plays itself out.
On Wednesday, Hamas loyalists clashed with Egyptian troops over Egypt's border wall. An Egyptian border guard was killed and seven Gazans were wounded in a brief exchange of fire.
Egypt's Foreign Ministry issued a stern warning, saying it would not stand for another violent protest on the border. Some, meanwhile, have questioned the effectiveness of the steel wall, saying tunnel smugglers could simply dig deeper.
Khaled Hroub, a Hamas expert and lecturer at Cambridge University, said he believes the recent developments will restrict Hamas' military options, but not its control over Gaza.